Progesterone is produced from the ovaries and is very low in women until ovulation, when progesterone levels start to rise to a peak at day 20-22 of the menstrual cycle. It declines by 80% in the Peri-menopause (leading up to the menopause) and symptoms of low mood, irritability, and depression can occur. In normal menstruating women who experience PMS symptoms, Progesterone may be low. Natural Progesterone has been used for many years to oppose Oestrogen in Bio-identical Hormone Replacement treatment and helps to balance Oestrogen. Progesterone has many positive benefits. It acts as a mild diuretic and reduces any fluid retention caused by Oestrogen. It has a mild sedative effect by increasing GABA (a neurotransmitter) in the brain, acting as a mild natural tranquiliser. Progesterone prevents sleep disturbances by increasing deep sleep, both degree and duration.
In the correct dosage and route of administration, Progesterone in post-menopausal women protects the lining of the uterus from increasing. New data has also demonstrated that micronized Progesterone enhances recovery from stroke.
Natural micronized Progesterone also has benefits on the cardiovascular system, decreasing atherosclerotic plaque formation and increasing arterial blood flow.
Most women report that progesterone has beneficial calming effects in the correct dose so the correct balance between bio-identical oestrogen and natural micronized Progesterone is important.
Natural Progesterone is anti-inflammatory and neuro-protective. Progesterone is decreased during stress and is low in the menopause and Peri-menopause. At the time of the menopause Thyroid function can also be low. This can cause low mood, tiredness, depression and low sex drive.
It is usual to measure and replace all hormones in balance, this may include Oestrogen, Progesterone, Testosterone and DHEA, Melatonin and Pregnenalone.